OSGEPL1

Across TCGA patient cohorts, OSGEPL1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSGEPL1-associated genes across cancer lineages are eIF4E, GSK-3a-b_pS21_S9, and JNK2. Each is linked with OSGEPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OSGEPL1-to-partner and partner-to-OSGEPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by OSGEPL1-low versus OSGEPL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSGEPL1→partner) and Y-score (partner→OSGEPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.220	+3.000	.011	.001	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.395	+2.321	.025	.006	3	1
UCEC	JNK2 →	+0.203	+1.807	.013	.027	3	1
UCEC	p21 →	+0.181	+2.459	.022	.019	3	1
UCEC	Akt_pS473 →	+0.653	+1.807	.027	.027	3	1
UCEC	Akt_pT308 →	+0.606	+1.807	.019	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

eIF4E by OSGEPL1 expression — UCEC

Explore this box plot interactively →