OSGEP

Across TCGA pan-cancer cohorts, OSGEP mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated OSGEP data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher OSGEP mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated OSGEP expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

HNSC, PDAC, and COAD are the cancer types where OSGEP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	III,IV	0.529	0.883	<.001	46	view →
PDAC	DFS	Tertile	III,IV	0.895	0.514	.002	22	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
LUAD	DFS	Median	II,III,IV	0.386	0.758	.018	6	view →
CCRCC	DFS	Quartile	All	0.887	1.000	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

OSGEP–HNSC (OS)

Open the HNSC breakdown →