OSGEP

Across TCGA cell cohorts, OSGEP mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OSGEP-associated genes across cancer lineages are C5orf52, SLCO1C1, and PROP1. Each is linked with OSGEP in more than 1 cancer types. Because this analysis shows association rather than direction, both OSGEP-to-partner and partner-to-OSGEP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C5orf52 grouped by OSGEP-low versus OSGEP-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSGEP→partner) and Y-score (partner→OSGEP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C5orf52 →	+0.027	+5.569	<.001	.001	3	1
LARGE_INTESTINE	SLCO1C1 →	+0.377	+3.772	.001	.003	3	1
LARGE_INTESTINE	PROP1 →	+0.020	+3.376	<.001	.002	3	1
LARGE_INTESTINE	ASCL3 →	+0.164	+3.617	<.001	.004	3	1
LARGE_INTESTINE	ELOA3DP →	+0.030	+3.103	<.001	.004	3	1
LARGE_INTESTINE	USP17L2 →	+0.040	+4.078	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

C5orf52 by OSGEP expression — BLOOD_Leukemia

Explore this box plot interactively →