OSER1

Across TCGA patient cohorts, OSER1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSER1-associated genes across cancer lineages are Ku80, MAPK_pT202_Y204, and MEK1_p_S217_S221. Each is linked with OSER1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OSER1-to-partner and partner-to-OSER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by OSER1-low versus OSER1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSER1→partner) and Y-score (partner→OSER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.237	+1.887	.031	.031	3	1
UCEC	MAPK_pT202_Y204 →	-0.553	-2.584	.011	.011	3	1
UCEC	MEK1_p_S217_S221 →	-0.296	-2.321	.020	.034	3	1
UCEC	Notch1 →	+0.238	+3.700	<.001	.001	3	1
UCEC	PEA-15_pS116 →	-0.390	-2.584	.017	.011	3	1
UCEC	Rab11 →	-0.154	-3.169	.023	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Ku80 by OSER1 expression — UCEC

Explore this box plot interactively →