OSER1

Across TCGA cell cohorts, OSER1 mutation is significantly associated with the drug of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OSER1-associated genes across cancer lineages are JAK3_7406, PARP_9495, and GSK429286A. Each is linked with OSER1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OSER1-to-partner and partner-to-OSER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JAK3_7406 grouped by OSER1-low versus OSER1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSER1→partner) and Y-score (partner→OSER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	JAK3_7406 →	+0.480	+2.649	.018	.046	3	1
LARGE_INTESTINE	PARP_9495 →	+0.430	+2.777	.044	.038	3	1
LARGE_INTESTINE	GSK429286A →	+0.366	+2.652	.018	.045	2	1
LARGE_INTESTINE	eEF2K Inhibitor →	+0.229	+2.652	.039	.045	2	1
LARGE_INTESTINE	AZD4877 →	+0.871	+2.649	.011	.046	1	1
LARGE_INTESTINE	PARP_9482 →	+0.735	+2.777	.027	.038	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

JAK3_7406 by OSER1 expression — LARGE_INTESTINE

Explore this box plot interactively →