OSCAR

Across TCGA pan-cancer cohorts, OSCAR mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated OSCAR data layer compared with 21 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher OSCAR mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated OSCAR expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where OSCAR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.909	0.634	.009	26	view →
PDAC	OS	Tertile	II,III,IV	0.100	0.935	.024	13	view →
CCRCC	DFS	Median	All	0.232	1.000	.017	7	view →
GBM	OS	Tertile	All	0.425	0.645	.005	6	view →
LSCC	DFS	Median	All	0.908	0.981	.012	5	view →
LUAD	OS	Median	II,III,IV	0.874	0.468	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

OSCAR–HNSC (OS)

Open the HNSC breakdown →