OSCAR

Across TCGA patient cohorts, OSCAR mutation is significantly associated with the RNA expression of many other genes, with 571 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSCAR-associated genes across cancer lineages are RNA5SP453, DNM1P38, and RNU6-1054P. Each is linked with OSCAR in more than 2 cancer types. Because this analysis shows association rather than direction, both OSCAR-to-partner and partner-to-OSCAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP453 grouped by OSCAR-low versus OSCAR-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSCAR→partner) and Y-score (partner→OSCAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP453 →	+0.187	+4.385	<.001	.008	3	3
LIHC	DNM1P38 →	+0.154	+5.014	<.001	.002	3	2
LIHC	RNU6-1054P →	+0.648	+4.690	<.001	.003	3	2
LIHC	RNU7-59P →	+0.899	+4.690	<.001	.003	3	2
SKCM	RN7SKP196 →	+0.065	+5.408	<.001	.002	3	2
SKCM	RN7SL470P →	+0.138	+4.351	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 571 associations by consensus.

RNA5SP453 by OSCAR expression — SKCM

Explore this box plot interactively →