OSCAR

Across TCGA patient cohorts, OSCAR mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSCAR-associated genes across cancer lineages are EGFR_pY1068, p38-MAPK_pT180_Y182, and Annexin-1. Each is linked with OSCAR in more than 1 cancer types. Because this analysis shows association rather than direction, both OSCAR-to-partner and partner-to-OSCAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by OSCAR-low versus OSCAR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSCAR→partner) and Y-score (partner→OSCAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.325	-3.459	.009	.005	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.547	-2.308	.015	.036	3	1
UCEC	Annexin-1 →	+0.965	+3.189	<.001	.010	3	1
UCEC	Shc_pY317 →	-0.216	-3.169	.004	.019	3	1
UCEC	TFRC →	+0.805	+3.459	.002	.005	3	1
UCEC	TIGAR →	+0.172	+2.348	.024	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

EGFR_pY1068 by OSCAR expression — UCEC

Explore this box plot interactively →