OSCAR

Across TCGA cell cohorts, OSCAR RNA expression is significantly associated with the go_rna of many other GO terms, with 2,415 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible OSCAR-associated GO terms across cancer lineages are Negative regulation of hyaluronan biosynthetic process, Regulation of protein K48-linked ubiquitination, and Positive regulation of ferroptosis. Each is linked with OSCAR in more than 8 cancer types. Because this analysis shows association rather than direction, both OSCAR-to-partner and partner-to-OSCAR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of hyaluronan biosynthetic process grouped by OSCAR-low versus OSCAR-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OSCAR→partner) and Y-score (partner→OSCAR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of hyaluronan biosynthetic process →	+0.181	+0.485	.001	.005	3	9
STOMACH	Regulation of protein K48-linked ubiquitination →	+0.146	+0.656	<.001	.002	3	8
OVARY	Positive regulation of ferroptosis →	+0.122	+1.467	.003	<.001	3	8
BLOOD_Lymphoma	Protein folding →	+0.049	+0.836	<.001	.002	3	7
SOFT_TISSUE	Striated muscle contraction →	+0.105	+0.738	<.001	<.001	3	7
SOFT_TISSUE	Dentinogenesis →	+1.029	+0.696	.006	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,415 associations by consensus.

Negative regulation of hyaluronan biosynthetic process by OSCAR expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →