OSBPL9

Across TCGA pan-cancer cohorts, OSBPL9 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of OSBPL9’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where OSBPL9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OSBPL9 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KICH, and BLCA are the cancer types where OSBPL9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OSBPL9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.141	<.001	11	view →
KICH	Female	II,III,IV	−1.475	<.001	10	view →
BLCA	All	III,IV	+0.608	<.001	9	view →
THCA	Male	II,III,IV	−0.557	.001	9	view →
BRCA	Female	All	−0.432	<.001	8	view →
KIRC	Male	II,III,IV	−0.474	<.001	6	view →
STAD	All	II,III,IV	+0.349	.026	4	view →
LIHC	Female	All	+0.561	.001	3	view →
LUAD	Female	II,III,IV	−0.358	.004	3	view →
LUSC	All	All	−0.317	<.001	3	view →
UCEC	All	All	−0.383	.043	2	view →
CHOL	All	All	+0.912	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

OSBPL9–HNSC

Open the HNSC breakdown →