OSBPL3

Across TCGA pan-cancer cohorts, OSBPL3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated OSBPL3 data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher OSBPL3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated OSBPL3 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LUAD, CCRCC, and HNSC are the cancer types where OSBPL3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.680	0.237	.015	10	view →
CCRCC	OS	Median	All	0.904	0.984	.028	5	view →
HNSC	DFS	Median	III,IV	0.708	0.858	.022	5	view →
GBM	OS	Median	All	0.664	0.862	.041	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

OSBPL3–LUAD (DFS)

Open the LUAD breakdown →