OSBPL3

Across TCGA patient cohorts, OSBPL3 mutation is significantly associated with the RNA expression of many other genes, with 3,906 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSBPL3-associated genes across cancer lineages are TRAJ28, TLE6, and ERAL1. Each is linked with OSBPL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both OSBPL3-to-partner and partner-to-OSBPL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ28 grouped by OSBPL3-low versus OSBPL3-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL3→partner) and Y-score (partner→OSBPL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	TRAJ28 →	+0.498	+5.463	<.001	<.001	3	3
SKCM	TLE6 →	+0.722	+2.594	<.001	.006	3	3
SKCM	ERAL1 →	+0.339	+2.613	.004	.005	3	3
SKCM	PREB →	+0.296	+3.407	.007	.004	3	3
SKCM	DTL →	+0.679	+3.497	.002	.002	3	3
LUAD	DIS3L2P1 →	+0.222	+2.987	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,906 associations by consensus.

TRAJ28 by OSBPL3 expression — LIHC

Explore this box plot interactively →