OSBPL3

Across TCGA patient cohorts, OSBPL3 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSBPL3-associated genes across cancer lineages are Rad50, ERK2, and INPP4B. Each is linked with OSBPL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OSBPL3-to-partner and partner-to-OSBPL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by OSBPL3-low versus OSBPL3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL3→partner) and Y-score (partner→OSBPL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Rad50 →	+0.157	+3.584	.035	.002	3	2
SKCM	ERK2 →	+0.278	+3.321	.011	.010	3	2
UCEC	INPP4B →	-0.191	-1.321	.045	.024	3	2
UCEC	MEK1 →	+0.419	+1.857	<.001	<.001	3	2
UCEC	MSH2 →	-0.222	-2.061	.001	.004	3	2
UCEC	Notch1 →	+0.145	+1.861	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Rad50 by OSBPL3 expression — BLCA

Explore this box plot interactively →