OSBPL3

Across TCGA cell cohorts, OSBPL3 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OSBPL3-associated genes across cancer lineages are OR1L6, GDF2, and C2orf42. Each is linked with OSBPL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OSBPL3-to-partner and partner-to-OSBPL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L6 grouped by OSBPL3-low versus OSBPL3-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL3→partner) and Y-score (partner→OSBPL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR1L6 →	+0.038	+5.029	<.001	.006	3	1
LUNG_SCLC	GDF2 →	+0.023	+5.643	<.001	.002	3	1
LARGE_INTESTINE	C2orf42 →	+0.798	+3.169	<.001	.005	3	1
LARGE_INTESTINE	PRMT9 →	+0.670	+3.192	<.001	.007	3	1
LARGE_INTESTINE	CRK →	+0.599	+3.067	.004	.009	3	1
LARGE_INTESTINE	ACER1 →	+0.090	+2.560	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

OR1L6 by OSBPL3 expression — LUNG_SCLC

Explore this box plot interactively →