OSBPL2

Across TCGA pan-cancer cohorts, OSBPL2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated OSBPL2 data layer compared with 20 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher OSBPL2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated OSBPL2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and GBM are the cancer types where OSBPL2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	1.000	0.724	.014	25	view →
HNSC	DFS	Tertile	All	0.760	0.520	.013	17	view →
GBM	DFS	Quartile	All	0.231	0.606	.003	16	view →
LUAD	DFS	Quartile	II,III,IV	0.232	0.873	.004	11	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
LSCC	DFS	Quartile	All	0.454	1.000	.026	5	view →
PDAC	OS	Median	II,III,IV	0.885	0.802	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

OSBPL2–CCRCC (DFS)

Open the CCRCC breakdown →