OSBPL2

Across TCGA patient cohorts, OSBPL2 mutation is significantly associated with the RNA expression of many other genes, with 2,757 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSBPL2-associated genes across cancer lineages are RN7SKP286, RNU6-522P, and RN7SL63P. Each is linked with OSBPL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both OSBPL2-to-partner and partner-to-OSBPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP286 grouped by OSBPL2-low versus OSBPL2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL2→partner) and Y-score (partner→OSBPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SKP286 →	+0.046	+4.640	<.001	.003	3	3
LUSC	RNU6-522P →	+1.192	+5.337	<.001	.006	3	3
LUSC	RN7SL63P →	+0.636	+4.984	<.001	.009	3	3
UCEC	RNU1-17P →	+0.180	+2.087	<.001	.009	3	3
LIHC	RNU6-716P →	+0.416	+5.544	<.001	.004	3	2
LIHC	KRTAP8-3P →	+0.249	+5.544	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,757 associations by consensus.

RN7SKP286 by OSBPL2 expression — SKCM

Explore this box plot interactively →