OSBPL2

Across TCGA patient cohorts, OSBPL2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSBPL2-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and eEF2. Each is linked with OSBPL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OSBPL2-to-partner and partner-to-OSBPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by OSBPL2-low versus OSBPL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL2→partner) and Y-score (partner→OSBPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.688	+1.894	.003	.030	3	2
UCEC	14-3-3_beta →	-0.088	-3.295	.025	.009	3	1
UCEC	eEF2 →	+0.429	+2.000	.002	.010	3	1
UCEC	EGFR_pY1068 →	-0.283	-2.502	.004	.002	3	1
UCEC	A-Raf_pS299 →	-0.134	-2.584	.004	.010	3	1
UCEC	ERK2 →	+0.292	+2.906	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Caspase-7-cleavedD198 by OSBPL2 expression — UCEC

Explore this box plot interactively →