OSBPL2

Across TCGA cell cohorts, OSBPL2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OSBPL2-associated genes across cancer lineages are AVP, ZAN, and FTMT. Each is linked with OSBPL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OSBPL2-to-partner and partner-to-OSBPL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by OSBPL2-low versus OSBPL2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL2→partner) and Y-score (partner→OSBPL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	AVP →	+0.130	+5.977	<.001	.001	3	1
SOFT_TISSUE	ZAN →	+0.006	+5.369	<.001	.004	3	1
SOFT_TISSUE	FTMT →	+0.086	+5.977	<.001	.001	3	1
LARGE_INTESTINE	ACER1 →	+0.083	+4.145	.003	.001	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	ADAM7 →	+0.004	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

AVP by OSBPL2 expression — SOFT_TISSUE

Explore this box plot interactively →