OSBPL1A

Across TCGA pan-cancer cohorts, OSBPL1A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated OSBPL1A data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher OSBPL1A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated OSBPL1A expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and UCEC are the cancer types where OSBPL1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	1.000	0.484	.038	12	view →
PDAC	OS	Tertile	All	0.598	0.410	.019	11	view →
UCEC	DFS	Quartile	III,IV	0.288	1.000	.040	10	view →
CCRCC	DFS	Quartile	III,IV	0.795	0.413	.009	9	view →
GBM	OS	Median	All	0.210	0.528	.004	6	view →
LUAD	DFS	Quartile	All	0.783	0.327	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

OSBPL1A–HNSC (OS)

Open the HNSC breakdown →