OSBPL1A

Across TCGA cell cohorts, OSBPL1A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,044 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible OSBPL1A-associated GO terms across cancer lineages are Lysosome to ER cholesterol transport, Intracellular cholesterol transport, and GCN2-mediated signaling. Each is linked with OSBPL1A in more than 10 cancer types. Because this analysis shows association rather than direction, both OSBPL1A-to-partner and partner-to-OSBPL1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lysosome to ER cholesterol transport grouped by OSBPL1A-low versus OSBPL1A-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL1A→partner) and Y-score (partner→OSBPL1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Lysosome to ER cholesterol transport →	+0.188	+1.286	<.001	<.001	3	11
SKIN	Intracellular cholesterol transport →	+0.086	+0.838	<.001	<.001	3	10
LUNG_NSCLC_LUSC	GCN2-mediated signaling →	+0.194	+1.056	.001	.006	2	9
BREAST	Regulation of sterol biosynthetic process →	+0.145	+1.336	<.001	<.001	3	7
BREAST	Regulation of cholesterol biosynthetic process →	+0.145	+1.336	<.001	<.001	3	7
BLOOD_Leukemia	Purine ribonucleoside salvage →	+0.170	+2.148	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,044 associations by consensus.

Lysosome to ER cholesterol transport by OSBPL1A expression — URINARY_TRACT

Explore this box plot interactively →