OSBPL1A

Across TCGA cell cohorts, OSBPL1A mutation is significantly associated with the RNA expression of many other genes, with 559 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OSBPL1A-associated genes across cancer lineages are FCN2, OR13D1, and SMIM23. Each is linked with OSBPL1A in more than 1 cancer types. Because this analysis shows association rather than direction, both OSBPL1A-to-partner and partner-to-OSBPL1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCN2 grouped by OSBPL1A-low versus OSBPL1A-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL1A→partner) and Y-score (partner→OSBPL1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	FCN2 →	+0.025	+4.087	<.001	.009	3	1
URINARY_TRACT	OR13D1 →	+0.032	+4.217	<.001	.005	3	1
URINARY_TRACT	SMIM23 →	+0.010	+4.087	<.001	.009	3	1
SOFT_TISSUE	CCDC185 →	+0.038	+3.635	<.001	.007	3	1
SOFT_TISSUE	USP17L11 →	+0.146	+3.865	<.001	.006	3	1
OESOPHAGUS	TAS2R39 →	+0.043	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 559 associations by consensus.

FCN2 by OSBPL1A expression — URINARY_TRACT

Explore this box plot interactively →