OSBPL1A

Across TCGA cell cohorts, OSBPL1A mutation is significantly associated with the mutation status of many other genes, with 3,967 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OSBPL1A-associated genes across cancer lineages are PHF2, MYO15A, and ABCA5. Each is linked with OSBPL1A in more than 5 cancer types. Because this analysis shows association rather than direction, both OSBPL1A-to-partner and partner-to-OSBPL1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHF2 grouped by OSBPL1A-low versus OSBPL1A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBPL1A→partner) and Y-score (partner→OSBPL1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PHF2 →	+2.108	+2.614	.001	.001	1	6
URINARY_TRACT	MYO15A →	+3.087	+4.000	.008	.008	1	5
LARGE_INTESTINE	ABCA5 →	+1.819	+2.392	.003	.003	1	5
STOMACH	ATAD2B →	+4.285	+3.357	.005	.005	1	5
LARGE_INTESTINE	UBE4B →	+2.734	+2.734	<.001	<.001	1	5
UPPER_AERODIGESTIVE_TRACT	ZNF395 →	+4.954	+4.392	.008	.008	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,967 associations by consensus.

PHF2 by OSBPL1A expression — LARGE_INTESTINE

Explore this box plot interactively →