OSBPL10

Across TCGA pan-cancer cohorts, OSBPL10 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of OSBPL10’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where OSBPL10 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types OSBPL10 is over-expressed in tumor, although a few such as CCRCC and LSCC show the opposite, repressed pattern.

CCRCC, PDAC, and LSCC are the cancer types where OSBPL10 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OSBPL10 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	II,III,IV	−0.224	<.001	10	view →
PDAC	Female	All	+0.839	<.001	8	view →
LSCC	Female	II,III,IV	−0.400	<.001	8	view →
COAD	All	II,III,IV	+0.191	.006	6	view →
LUAD	All	All	+0.157	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

OSBPL10–CCRCC

Open the CCRCC breakdown →