Across TCGA patient cohorts, OSBP2 mutation is significantly associated with the RNA expression of many other genes, with 5,178 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSBP2-associated genes across cancer lineages are CHAF1A, SHCBP1, and UHRF1. Each is linked with OSBP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both OSBP2-to-partner and partner-to-OSBP2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBP2→partner) and Y-score (partner→OSBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHAF1A →	+0.814	+2.828	<.001	<.001	3	4
UCEC	SHCBP1 →	+0.784	+3.928	<.001	<.001	3	4
UCEC	UHRF1 →	+1.145	+3.917	<.001	<.001	3	3
UCEC	FEN1 →	+0.751	+2.839	<.001	<.001	3	3
SKCM	CDCA4 →	+0.493	+2.093	.002	.003	3	3
UCEC	KPNA2 →	+0.702	+3.273	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,178 associations by consensus.

Exploration

OSBP2 survival (RNA) · tumor vs normal (RNA) · all OSBP2 data types