Across TCGA patient cohorts, OSBP2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSBP2-associated genes across cancer lineages are PDCD4, EGFR_pY1068, and eIF4E. Each is linked with OSBP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both OSBP2-to-partner and partner-to-OSBP2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBP2→partner) and Y-score (partner→OSBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.616	-2.990	<.001	<.001	3	3
UCEC	EGFR_pY1068 →	-0.237	-1.736	.006	.007	3	2
UCEC	eIF4E →	+0.221	+4.087	.002	<.001	3	2
UCEC	FoxM1 →	+0.273	+2.070	.002	.001	3	2
UCEC	FOXO3a_pS318_S321 →	-0.109	-1.906	.011	.014	3	2
UCEC	Ku80 →	+0.222	+1.453	.006	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Exploration

OSBP2 survival (RNA) · tumor vs normal (RNA) · all OSBP2 data types