OSBP

Across TCGA patient cohorts, OSBP RNA expression is significantly associated with the mutation status of many other genes, with 9,542 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSBP-associated genes across cancer lineages are DNAH10, ZNF536, and SORCS1. Each is linked with OSBP in more than 4 cancer types. Because this analysis shows association rather than direction, both OSBP-to-partner and partner-to-OSBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAH10 grouped by OSBP-low versus OSBP-high in COAD.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBP→partner) and Y-score (partner→OSBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DNAH10 →	+1.632	+0.255	<.001	.001	3	5
UCEC	ZNF536 →	+2.200	+0.380	<.001	<.001	3	5
READ	SORCS1 →	+3.404	+0.533	.003	.002	3	4
LUSC	DSCAM →	+1.725	+0.284	<.001	<.001	3	4
UCEC	DOCK2 →	+1.808	+0.305	<.001	<.001	3	4
STAD	NAV3 →	+2.452	+0.374	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,542 associations by consensus.

DNAH10 by OSBP expression — COAD

Explore this box plot interactively →