OSBP

Across TCGA patient cohorts, OSBP protein abundance is significantly associated with the RNA expression of many other genes, with 12,663 significant associations in total. GBM shows the largest number of these associations.

The most reproducible OSBP-associated genes across cancer lineages are GJC1, TMX2, and TIMP2. Each is linked with OSBP in more than 4 cancer types. Because this analysis shows association rather than direction, both OSBP-to-partner and partner-to-OSBP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, OSBP versus GJC1 in CCRCC, with a Pearson correlation of -0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBP→partner) and Y-score (partner→OSBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GJC1 →	-0.954	-0.160	<.001	<.001	3	5
COAD	TMX2 →	+0.377	+0.170	.001	<.001	3	5
OV	TIMP2 →	-1.008	-0.228	<.001	<.001	3	5
OV	SOX18 →	-0.979	-0.242	<.001	<.001	3	5
OV	ADARB1 →	-0.677	-0.183	.001	.008	3	5
UCEC	C18orf54 →	-0.857	-0.168	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,663 associations by consensus.

OSBP vs GJC1 — CCRCC

Explore this scatter interactively →