OSBP

Across TCGA patient cohorts, OSBP mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OSBP-associated genes across cancer lineages are MEK1_p_S217_S221, Notch1, and PKC-b-II_pS660. Each is linked with OSBP in more than 1 cancer types. Because this analysis shows association rather than direction, both OSBP-to-partner and partner-to-OSBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1_p_S217_S221 grouped by OSBP-low versus OSBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OSBP→partner) and Y-score (partner→OSBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1_p_S217_S221 →	-0.221	-1.502	.027	.030	3	2
UCEC	Notch1 →	+0.180	+2.247	<.001	.001	3	2
UCEC	PKC-b-II_pS660 →	-0.280	-1.874	.005	.049	3	2
UCEC	STAT3_pY705 →	-0.398	-1.906	<.001	.014	3	2
UCEC	c-Met_pY1235 →	+0.071	+1.916	.009	.009	3	2
UCEC	eEF2 →	+0.267	+2.321	.042	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

MEK1_p_S217_S221 by OSBP expression — UCEC

Explore this box plot interactively →