OS9

Across TCGA pan-cancer cohorts, OS9 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated OS9 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher OS9 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated OS9 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

CCRCC, PDAC, and OV are the cancer types where OS9 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.728	0.949	<.001	58	view →
PDAC	OS	Tertile	II,III,IV	0.260	0.515	.001	47	view →
OV	DFS	Median	All	0.579	1.000	.005	8	view →
GBM	DFS	Quartile	All	0.674	0.889	.007	8	view →
HNSC	DFS	Median	IV	1.000	0.413	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

OS9–CCRCC (OS)

Open the CCRCC breakdown →