OS9

Across TCGA patient cohorts, OS9 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OS9-associated genes across cancer lineages are Notch1, p62 Lck ligand, and EGFR_pY1068. Each is linked with OS9 in more than 1 cancer types. Because this analysis shows association rather than direction, both OS9-to-partner and partner-to-OS9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by OS9-low versus OS9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OS9→partner) and Y-score (partner→OS9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.224	+2.415	<.001	.003	3	2
UCEC	p62 Lck ligand →	+0.750	+4.169	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.302	-2.415	.002	.003	3	1
UCEC	HER2_pY1248 →	-0.215	-4.169	.046	<.001	3	1
UCEC	IGFBP2 →	-0.699	-1.906	.007	.016	3	1
UCEC	JNK2 →	+0.257	+1.906	.001	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Notch1 by OS9 expression — UCEC

Explore this box plot interactively →