OS9

Across TCGA cell cohorts, OS9 mutation is significantly associated with the drug of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OS9-associated genes across cancer lineages are UNC0642, PI3Ka_4409, and GSK2110183B. Each is linked with OS9 in more than 1 cancer types. Because this analysis shows association rather than direction, both OS9-to-partner and partner-to-OS9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UNC0642 grouped by OS9-low versus OS9-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OS9→partner) and Y-score (partner→OS9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UNC0642 →	+0.240	+2.658	.009	.043	3	1
LARGE_INTESTINE	PI3Ka_4409 →	-0.503	-2.743	.004	.046	3	1
LARGE_INTESTINE	GSK2110183B →	+0.590	+2.871	.041	.021	3	1
LARGE_INTESTINE	50869 →	+0.590	+2.871	.002	.021	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.706	+2.868	.002	.022	3	1
LARGE_INTESTINE	TGX221 →	+0.588	+2.514	.023	.040	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

UNC0642 by OS9 expression — LARGE_INTESTINE

Explore this box plot interactively →