ORMDL2

Across TCGA cell cohorts, ORMDL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,848 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible ORMDL2-associated GO terms across cancer lineages are CAAX-box protein processing, GDP-mannose biosynthetic process, and Protein insertion into ER membrane by stop-transfer membrane-anchor sequence. Each is linked with ORMDL2 in more than 11 cancer types. Because this analysis shows association rather than direction, both ORMDL2-to-partner and partner-to-ORMDL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CAAX-box protein processing grouped by ORMDL2-low versus ORMDL2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ORMDL2→partner) and Y-score (partner→ORMDL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CAAX-box protein processing →	+0.136	+0.760	<.001	.003	2	12
LUNG_NSCLC_LUAD	GDP-mannose biosynthetic process →	+0.061	+0.420	.002	.002	3	9
LARGE_INTESTINE	Protein insertion into ER membrane by stop-transfer membrane-anchor sequence →	+0.093	+0.855	<.001	<.001	3	8
CNS	Negative regulation of ceramide biosynthetic process →	+0.130	+0.486	<.001	.003	3	8
LARGE_INTESTINE	Maintenance of protein localization in endoplasmic reticulum →	+0.080	+0.563	.008	.001	3	7
BONE	Regulation of mitochondrion organization →	+0.077	+0.502	.008	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,848 associations by consensus.

CAAX-box protein processing by ORMDL2 expression — LUNG_SCLC

Explore this box plot interactively →