ORMDL1

Across TCGA pan-cancer cohorts, ORMDL1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ORMDL1 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ORMDL1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ORMDL1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LUAD, UCEC, and LSCC are the cancer types where ORMDL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.282	0.730	.035	11	view →
UCEC	OS	Median	II,III,IV	0.284	1.000	.037	4	view →
LSCC	OS	Median	II,III,IV	1.000	0.877	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ORMDL1–LUAD (DFS)

Open the LUAD breakdown →