ORMDL1

Across TCGA patient cohorts, ORMDL1 protein abundance is significantly associated with the RNA expression of many other genes, with 3,744 significant associations in total. OV shows the largest number of these associations.

The most reproducible ORMDL1-associated genes across cancer lineages are SIGLEC5, HSPB1, and EIF3B. Each is linked with ORMDL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORMDL1-to-partner and partner-to-ORMDL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ORMDL1 versus SIGLEC5 in OV, with a Pearson correlation of -0.27.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORMDL1→partner) and Y-score (partner→ORMDL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SIGLEC5 →	-0.112	-0.983	<.001	.001	3	2
UCEC	HSPB1 →	-1.235	-0.471	.003	.007	3	2
UCEC	EIF3B →	-0.984	-0.687	.004	.003	3	2
UCEC	LGALS3BP →	-1.268	-0.859	.009	<.001	3	2
UCEC	GOT2 →	-0.714	-0.536	.008	.009	3	2
UCEC	CCT5 →	-1.175	-0.790	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,744 associations by consensus.

ORMDL1 vs SIGLEC5 — OV

Explore this scatter interactively →