ORMDL1

Across TCGA cell cohorts, ORMDL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,666 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ORMDL1-associated GO terms across cancer lineages are Peptidyl-serine autophosphorylation, Non-motile cilium assembly, and Medulla oblongata development. Each is linked with ORMDL1 in more than 15 cancer types. Because this analysis shows association rather than direction, both ORMDL1-to-partner and partner-to-ORMDL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-serine autophosphorylation grouped by ORMDL1-low versus ORMDL1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ORMDL1→partner) and Y-score (partner→ORMDL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Peptidyl-serine autophosphorylation →	+0.115	+0.528	<.001	.002	3	16
UPPER_AERODIGESTIVE_TRACT	Non-motile cilium assembly →	+0.046	+0.774	.007	.002	2	13
KIDNEY	Medulla oblongata development →	+0.101	+0.761	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Positive regulation of organelle assembly →	+0.060	+0.955	.001	.001	3	10
UPPER_AERODIGESTIVE_TRACT	Termination of RNA polymerase II transcription →	+0.113	+1.100	<.001	<.001	3	10
OVARY	Golgi vesicle transport →	+0.042	+0.638	.002	.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,666 associations by consensus.

Peptidyl-serine autophosphorylation by ORMDL1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →