Across TCGA patient cohorts, ORM1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ORM1-associated genes across cancer lineages are eIF4G, A-Raf_pS299, and IRS1. Each is linked with ORM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORM1-to-partner and partner-to-ORM1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORM1→partner) and Y-score (partner→ORM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.317	+2.115	.019	.019	3	1
UCEC	A-Raf_pS299 →	-0.140	-3.000	.007	.036	3	1
UCEC	IRS1 →	+0.244	+2.999	.007	.035	3	1
UCEC	Ku80 →	+0.251	+1.598	.015	.044	3	1
UCEC	mTOR_pS2448 →	-0.165	-3.439	.011	.005	3	1
UCEC	p62 Lck ligand →	+0.480	+3.469	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

ORM1 survival (RNA) · tumor vs normal (RNA) · all ORM1 data types