ORC5

Across TCGA pan-cancer cohorts, ORC5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ORC5 data layer compared with 19 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ORC5 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ORC5 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, HNSC, and CCRCC are the cancer types where ORC5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	1.000	0.655	.003	21	view →
HNSC	OS	Tertile	II,III,IV	0.790	0.923	.013	14	view →
CCRCC	DFS	Tertile	II,III,IV	0.764	0.953	.007	11	view →
LUAD	OS	Quartile	All	0.597	1.000	.007	7	view →
GBM	OS	Median	All	0.662	0.404	<.001	7	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ORC5–LSCC (OS)

Open the LSCC breakdown →