ORC5

Across TCGA patient cohorts, ORC5 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,998 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ORC5-associated proteins across cancer lineages are PUS7, HSPA14, and BUD23. Each is linked with ORC5 in more than 8 cancer types. Because this analysis shows association rather than direction, both ORC5-to-partner and partner-to-ORC5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ORC5 versus PUS7 in LSCC, with a Pearson correlation of 0.71.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC5→partner) and Y-score (partner→ORC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PUS7 →	+0.571	+0.731	<.001	<.001	3	9
HNSC	HSPA14 →	+0.433	+1.022	<.001	<.001	3	8
COAD	BUD23 →	+0.464	+0.496	<.001	<.001	3	8
BRCA	DNAJC2 →	+0.412	+0.430	<.001	.002	3	8
OV	LRWD1 →	+0.434	+0.500	<.001	<.001	3	7
LSCC	THOC1 →	+0.276	+0.726	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,998 associations by consensus.

ORC5 vs PUS7 — LSCC

Explore this scatter interactively →