ORC5

Across TCGA patient cohorts, ORC5 protein abundance is significantly associated with the RNA expression of many other genes, with 18,261 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ORC5-associated genes across cancer lineages are DNAJC2, GINS1, and EZH2. Each is linked with ORC5 in more than 8 cancer types. Because this analysis shows association rather than direction, both ORC5-to-partner and partner-to-ORC5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ORC5 versus DNAJC2 in HNSC, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC5→partner) and Y-score (partner→ORC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DNAJC2 →	+0.717	+0.245	<.001	<.001	3	9
UCEC	GINS1 →	+0.937	+0.235	<.001	<.001	3	8
BRCA	EZH2 →	+0.927	+0.419	<.001	<.001	3	8
HNSC	MCM3 →	+1.352	+0.368	<.001	<.001	3	8
OV	FARSB →	+0.569	+0.248	<.001	.004	3	8
HNSC	DARS2 →	+0.660	+0.365	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,261 associations by consensus.

ORC5 vs DNAJC2 — HNSC

Explore this scatter interactively →