ORC5

Across TCGA cell cohorts, ORC5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,451 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ORC5-associated GO terms across cancer lineages are DNA-templated transcription termination, Peptidyl-glutamic acid carboxylation, and Protein carboxylation. Each is linked with ORC5 in more than 13 cancer types. Because this analysis shows association rather than direction, both ORC5-to-partner and partner-to-ORC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated transcription termination grouped by ORC5-low versus ORC5-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC5→partner) and Y-score (partner→ORC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	DNA-templated transcription termination →	+0.111	+1.366	<.001	<.001	3	14
BREAST	Peptidyl-glutamic acid carboxylation →	+0.112	+0.552	<.001	<.001	3	14
BREAST	Protein carboxylation →	+0.112	+0.552	<.001	<.001	3	14
SKIN	Positive regulation of isotype switching to IgG isotypes →	+0.136	+0.738	<.001	<.001	3	12
BLOOD_Myeloma	DNA replication initiation →	+0.174	+1.166	<.001	.001	2	13
BLOOD_Lymphoma	Interstrand cross-link repair →	+0.068	+0.870	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,451 associations by consensus.

DNA-templated transcription termination by ORC5 expression — BLOOD_Myeloma

Explore this box plot interactively →