ORC5

Across TCGA cell cohorts, ORC5 mutation is significantly associated with the drug of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ORC5-associated genes across cancer lineages are SGC-CBP30, CDK9_5576, and BDILV000379a. Each is linked with ORC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORC5-to-partner and partner-to-ORC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SGC-CBP30 grouped by ORC5-low versus ORC5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC5→partner) and Y-score (partner→ORC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SGC-CBP30 →	+0.327	+2.649	.020	.046	3	1
LARGE_INTESTINE	CDK9_5576 →	+0.553	+2.649	.034	.046	3	1
LARGE_INTESTINE	BDILV000379a →	+0.399	+2.649	.008	.046	1	1
LARGE_INTESTINE	IRAK4_4710 →	+0.545	+2.649	.002	.046	1	1
LARGE_INTESTINE	JAK1_8709 →	+0.575	+2.649	.002	.046	1	1
LARGE_INTESTINE	VSP34_8731 →	+0.433	+2.649	.031	.046	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

SGC-CBP30 by ORC5 expression — LARGE_INTESTINE

Explore this box plot interactively →