ORC3

Across TCGA patient cohorts, ORC3 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,142 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ORC3-associated proteins across cancer lineages are PM20D2, SCAF8, and SYNCRIP. Each is linked with ORC3 in more than 6 cancer types. Because this analysis shows association rather than direction, both ORC3-to-partner and partner-to-ORC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ORC3 versus PM20D2 in BRCA, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC3→partner) and Y-score (partner→ORC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PM20D2 →	+0.751	+0.462	.001	.001	3	7
GBM	SCAF8 →	+0.265	+0.441	<.001	<.001	3	7
LSCC	SYNCRIP →	+0.328	+0.592	<.001	<.001	3	7
GBM	BCLAF1 →	+0.381	+0.353	<.001	.003	3	6
LSCC	EFTUD2 →	+0.200	+0.573	<.001	<.001	3	6
UCEC	PPIL4 →	+0.241	+0.407	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,142 associations by consensus.

ORC3 vs PM20D2 — BRCA

Explore this scatter interactively →