ORC3

Across TCGA patient cohorts, ORC3 mutation is significantly associated with the RNA expression of many other genes, with 1,074 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ORC3-associated genes across cancer lineages are CDKN3, HCST, and DUOXA1. Each is linked with ORC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORC3-to-partner and partner-to-ORC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDKN3 grouped by ORC3-low versus ORC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC3→partner) and Y-score (partner→ORC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDKN3 →	+0.619	+3.467	.008	.002	3	2
UCEC	HCST →	+0.668	+3.467	.008	.002	3	2
UCEC	DUOXA1 →	-0.866	-2.692	.003	.006	3	2
UCEC	RNU6-48P →	+0.381	+1.932	.007	.003	3	2
UCEC	TRAJ31 →	+0.608	+1.787	.001	.006	3	2
UCEC	SRA1 →	+0.357	+3.269	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,074 associations by consensus.

CDKN3 by ORC3 expression — UCEC

Explore this box plot interactively →