ORC3

Across TCGA patient cohorts, ORC3 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ORC3-associated genes across cancer lineages are eEF2, PDCD4, and TIGAR. Each is linked with ORC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORC3-to-partner and partner-to-ORC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ORC3-low versus ORC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC3→partner) and Y-score (partner→ORC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.463	+2.459	.001	.018	3	2
UCEC	PDCD4 →	-0.676	-3.169	<.001	.018	3	2
UCEC	TIGAR →	+0.193	+2.348	.002	.003	3	2
UCEC	ASNS →	+0.515	+2.000	<.001	.030	3	2
UCEC	Caspase-7-cleavedD198 →	+0.786	+2.604	.001	.005	3	2
BLCA	CD20 →	+0.168	+2.833	.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

eEF2 by ORC3 expression — UCEC

Explore this box plot interactively →