ORC3

Across TCGA cell cohorts, ORC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,908 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ORC3-associated GO terms across cancer lineages are Regulation of chromosome segregation, Regulation of mitotic sister chromatid separation, and Regulation of metaphase/anaphase transition of cell cycle. Each is linked with ORC3 in more than 18 cancer types. Because this analysis shows association rather than direction, both ORC3-to-partner and partner-to-ORC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of chromosome segregation grouped by ORC3-low versus ORC3-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC3→partner) and Y-score (partner→ORC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of chromosome segregation →	+0.141	+1.161	<.001	<.001	3	19
URINARY_TRACT	Regulation of mitotic sister chromatid separation →	+0.164	+1.031	.001	<.001	3	18
KIDNEY	Regulation of metaphase/anaphase transition of cell cycle →	+0.148	+0.983	<.001	<.001	3	18
URINARY_TRACT	Negative regulation of metaphase/anaphase transition of cell cycle →	+0.175	+1.232	<.001	<.001	3	18
KIDNEY	Protein localization to condensed chromosome →	+0.180	+1.057	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Regulation of chromosome separation →	+0.135	+0.704	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,908 associations by consensus.

Regulation of chromosome segregation by ORC3 expression — KIDNEY

Explore this box plot interactively →