ORC3

Across TCGA cell cohorts, ORC3 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ORC3-associated genes across cancer lineages are SMIM23, AQP10, and OR1N2. Each is linked with ORC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORC3-to-partner and partner-to-ORC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM23 grouped by ORC3-low versus ORC3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC3→partner) and Y-score (partner→ORC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SMIM23 →	+0.018	+4.984	<.001	.002	3	2
KIDNEY	AQP10 →	+0.014	+4.491	<.001	.002	3	1
KIDNEY	OR1N2 →	+0.030	+4.954	<.001	<.001	3	1
KIDNEY	EIF4E1B →	+0.006	+4.121	<.001	.006	3	1
KIDNEY	OR6K3 →	+0.024	+4.954	<.001	<.001	3	1
LARGE_INTESTINE	SPRR2F →	+0.477	+3.707	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

SMIM23 by ORC3 expression — BLOOD_Leukemia

Explore this box plot interactively →