ORC2

Across TCGA patient cohorts, ORC2 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ORC2-associated genes across cancer lineages are FASN, FOXO3a_pS318_S321, and STAT3_pY705. Each is linked with ORC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORC2-to-partner and partner-to-ORC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by ORC2-low versus ORC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC2→partner) and Y-score (partner→ORC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.437	+2.584	.004	.010	3	2
UCEC	FOXO3a_pS318_S321 →	-0.105	-2.690	.032	.006	3	2
UCEC	STAT3_pY705 →	-0.429	-2.807	<.001	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.758	+2.827	.001	.001	3	2
UCEC	c-Met_pY1235 →	+0.068	+1.710	.019	.025	3	2
UCEC	Cyclin-B1 →	+0.751	+3.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

FASN by ORC2 expression — UCEC

Explore this box plot interactively →