ORC2

Across TCGA cell cohorts, ORC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,032 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ORC2-associated GO terms across cancer lineages are Replication fork processing, DNA-templated DNA replication maintenance of fidelity, and DNA replication. Each is linked with ORC2 in more than 17 cancer types. Because this analysis shows association rather than direction, both ORC2-to-partner and partner-to-ORC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Replication fork processing grouped by ORC2-low versus ORC2-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC2→partner) and Y-score (partner→ORC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Replication fork processing →	+0.142	+1.014	<.001	<.001	3	18
BLOOD_Myeloma	DNA-templated DNA replication maintenance of fidelity →	+0.132	+0.924	<.001	<.001	3	18
BLOOD_Myeloma	DNA replication →	+0.107	+0.930	<.001	<.001	3	17
BLOOD_Myeloma	DNA-templated DNA replication →	+0.153	+0.948	<.001	<.001	3	17
BLOOD_Myeloma	DNA replication initiation →	+0.217	+0.972	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Nuclear pore organization →	+0.130	+0.768	.003	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,032 associations by consensus.

Replication fork processing by ORC2 expression — BLOOD_Myeloma

Explore this box plot interactively →