ORC2

Across TCGA cell cohorts, ORC2 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ORC2-associated genes across cancer lineages are PDCL2, C9orf153, and FAM136A. Each is linked with ORC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ORC2-to-partner and partner-to-ORC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCL2 grouped by ORC2-low versus ORC2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ORC2→partner) and Y-score (partner→ORC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PDCL2 →	+0.164	+3.389	.002	.007	3	1
LARGE_INTESTINE	C9orf153 →	+0.138	+3.497	.002	.004	3	1
LARGE_INTESTINE	FAM136A →	+0.608	+3.082	<.001	.007	3	1
LARGE_INTESTINE	SIKE1 →	+0.620	+3.064	.006	.009	3	1
CNS	C3orf56 →	+0.022	+4.981	<.001	.008	3	1
LARGE_INTESTINE	HMGXB4 →	+0.570	+3.067	.008	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

PDCL2 by ORC2 expression — LARGE_INTESTINE

Explore this box plot interactively →