ORC1

Across TCGA pan-cancer cohorts, ORC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ORC1 data layer compared with 31 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ORC1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ORC1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where ORC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.870	0.275	.005	23	view →
PDAC	DFS	Quartile	All	0.680	0.186	.024	6	view →
HNSC	OS	Median	IV	0.854	0.594	.025	5	view →
GBM	DFS	Tertile	All	0.603	0.831	.030	3	view →
UCEC	DFS	Median	All	1.000	0.912	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ORC1–LSCC (DFS)

Open the LSCC breakdown →